Orenburg Oblast is a big agricultural producer in Russia and ranks among Russia's least interesting regions for tourism, with few, if any, sights worth traveling here to see. The Ural River, considered the boundary between Europe and Asia, cuts through its territory.
See Russian phrasebook.
Orenburg's main airport services flights to/from Moscow, Saint Petersburg, and Dushanbe
There are two trains from Moscow to Orenburg. One of them departs every odd day around 19:00 and takes 26 hours. And the second one departs every day per week around 15:00 and takes 30 hours.
Trains goes through Ryazan, Samara.
There is one train goes every day from and to Samara.
Trains head south to Kazakhstan and on to Uzbekistan from Orenburg and Orsk.