Getting around the site is easy, though it is large (several miles in either direction) it is a fairly easy walk. There is no formal disabled access, and much of the site is ruins. Wheelchair access might be possible (the paving in the collonade is still mostly intact), but you'd be trying your luck.
Several Syrian tour companies offer guided tours of the site, which usually include a meal at the restaurant.
There are several sets of ruins at the site, with more excavations still being undertaken in 2008. The collonade on the main street of Apamea is a mile long and, in true Roman style, is dead straight, providing interesting 'vanishing point' photography. There is also a citadel at the site, which has seen locals move in and build around it, and several, smaller ruins heading away from town on the access road.
Access to all of these parts of the site are paid for with one single ticket, worth only a few American dollars. You are then permitted to walk around most of the vast site by yourself. Several tourist guidebooks are available in sveral European languages.
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