This region of Nebraska is sparsely populated. Therefore, many places you go have a down home, small town feel. Though the small town feel will be apealing to most, it also means there is a lack of diversity.
There is a small but sizable minority of Hispanic people moving to the area yet not enough for a knowledge of the Spanish language would be required. The Oglala Lakota are a prominent Native American tribe in the region so you may be inclined to know some of their language and customs if you plan on visiting Pine Ridge. Also, at one time there was a large influx of Scandinavian and German immigrants to the region, though extremely uncommon there are still some areas that have elderly speakers of their native tongue.
For the most part people traveling along I-80 will see the southern part of the Panhandle. The major airport is Nebraska Western Regional Airport (BFF).
The recommended mode of transport through this area is by car. However, keep in mind that there areas of interest that can only be observed either by hiking or horseback riding. There are still some railroads that stop in this area.
Nebraska is known for its beef. While most of it is processed in Omaha, a lot of it is raised on ranches in the panhandle. This area is known for its authentic cowboy-style meals. Portions tend to be large and the food is heavy. Also Rocky Mountain Oysters are a popular and sometime humorous dish to consume in the Panhandle. They are fried bull testicles. Eating them is generally a sign of fertility and courage. Runzas, a German bread pocket full of beef and vegetables, are also popular throughout this region.
One thing to observe while ordering a beer in Nebraska is that beer poured into a glass is usually referred to as a draw.
This area is know for brutal blizzards in the winter and scorching summers. It is best to always check the weather here. This region does have several poisonous snakes that travelers should be aware of if they are planning on doing outdoor activities. This region also has sizable mountain lion, pronghorn, big horn sheep, mule deer, and wild turkeys. It is advised that people take great caution when dealing with wild life in Nebraska. However, crime in this area is considerably lower than other areas of the nation. It is common for people to leave their doors unlocked and show a great sense of hospitality for those in need. Be on your guard, do to the fact that these cities are sparsely spread out medical facilities are not common place so the best protection is prevention no matter what the case.
The Panhandle region of Nebraska is usually passed through on the way to Mount Rushmore National Memorial if you're coming from Texas or on the way to Yellowstone if you are coming from the Eastern Sea Board.