Although the Pennine way can be walked in either direction, general advice is to head from South to North. This way you tend to have the wind at your back, and most travel guides (including this one) are written in this direction.
The trail officially starts at The Nags Head pub in Edale. Edale is best access by train. Sheffield and Manchester are both around a 45 minute train journey away. Bus services to Edale are very limited.
The trail officially ends at The Border Inn in Kirk Yetholm. From here, a bus service links to Jedburgh via Kelso where further connections can be taken to Newcastle upon Tyne (total travel time approx 2 hours) and Edinburgh (total travel time approx 1 hour 45 minutes).