Midland is the closest commercial airport to Lajitas, approximately a 4 hour drive. El Paso is the next closest commercial airport to Lajitas, approximately a 5 hour drive.
There is a large private airport at Lajitas, owned by the Lajitas Resort [http://www.lajitas.com/hometxt.html] with a 7500 ft. (2286 m) runway. The airport has a landing fee for the aircraft of non-guests. Lajitas Air [http://www.flylajitas.com/] provides service from Austin (AUS) and Dallas-Love (DAL).
Rental cars are available at the Midland and El Paso airports.
From Midland-Odessa. Approximately 245 miles. Head West on IH-20 to Monahans. Take Highway 18 South (left) toward Fort Stockton, then turn right onto FM 1776. Cross over IH-10 West. FM 1776 turns into US-67 South. Follow US-67 55 miles to Alpine, then turn left onto SH-118 South (Cockrell Street). Follow SH-118 South 80 miles to the Study Butte/Terlingua junction, then turn right onto FM 170 and continue 14 miles to Lajitas.
From El Paso, approximately 300 miles. Take IH-10 East 118 miles to Van Horn. Take US-90 78 miles through Marfa. Continue to Alpine and turn right onto SH-118 South (Cockrell Street). Follow SH-118 South 80 miles to the Study Butte/Terlingua junction, then turn right onto FM 170 and continue 14 miles to Lajitas.